HCID 178501066, compound → HCID 178501054, compound

HRID 449080Notes

Reaction equation

HRID 449080 reaction equation
C(OC(=O)NC[C@H]1CC[C@H](C2N3C(C(N)=NC=N3)=C([C:28]3[CH:33]=[CH:32][C:31]([O:34][C:35]4[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=4)=[CH:30][CH:29]=3)N=2)CC1)C1C=CC=CC=1.[CH3:42][O:43][C:44]([C@H:46]1[CH2:51][CH2:50][C@H:49]([C:52]2[N:60]3[C:55]([C:56]([NH2:61])=[N:57][CH:58]=[N:59]3)=[C:54](I)[N:53]=2)[CH2:48][CH2:47]1)=[O:45]>>[CH3:42][O:43][C:44]([C@H:46]1[CH2:47][CH2:48][C@H:49]([C:52]2[N:60]3[C:55]([C:56]([NH2:61])=[N:57][CH:58]=[N:59]3)=[C:54]([C:28]3[CH:33]=[CH:32][C:31]([O:34][C:35]4[CH:36]=[CH:37][CH:38]=[CH:39][CH:40]=4)=[CH:30][CH:29]=3)[N:53]=2)[CH2:50][CH2:51]1)=[O:45]

Participants

3

Reactant 2

HCID 178501066HCID 178501066, compoundHCID 178508823HCID 178508823, compound

Product 1

HCID 178501054HCID 178501054, compound

Procedure

Prepared according to the procedure analogous to that described above for trans-{4-[4-amino-5-(4-phenoxy-phenyl)-imidazo[5,1-f][1,2,4]triazin-7-yl]-cyclohexylmethyl}-carbamic acid benzyl ester, except using trans-4-(4-amino-5-iodo-imidazo[5,1-f][1,2,4]triazin-7-yl)-cyclohexanecarboxylic acid methyl ester.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-7540685d11584d1e86e91272006ccde5
Source dataset
uspto-grants-2013_07
Patent number
US08481733B2

Reaction notes

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