N,N-Dimethylethylenediamine → HCID 178483777, compound

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Reaction Steps

A solution of toluene-4-sulfonic acid 4-[4-amino-5-(4-phenoxy-phenyl)-imidazo[5,1-f][1,2,4]triazin-7-yl]-cyclohexylmethyl ester (5.0 mg, 0.0088 mmol), N,N-dimethyl-1,2-ethanediamine (1 mL, 0.009 mol) in MeOH (1 mL) was heated in microwave reactor at 300 watt, 100° C. for 2 h. The solvent and excess amine were removed in vacuo, and the material was purified by silica gel chromatography, eluting with 5% (7N NH3 in MeOH) in DCM. HPLC: tR=1.99 min. (OpenLynx, polar—5 min). MS (ES+): m/z 486.19 (100) [MH+].

Provenance & Evidence