Dimethylamine → HCID 178483622, compound

HRID 449084Notes

Reaction equation

[NH2:1][C:2]1[C:7]2=[C:8]([C:24]3[CH:29]=[CH:28][C:27]([O:30][C:31]4[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=4)=[CH:26][CH:25]=3)[N:9]=[C:10]([C@H:11]3[CH2:16][CH2:15][C@H:14]([CH2:17][NH:18][CH2:19]CN(C)C)[CH2:13][CH2:12]3)[N:6]2[N:5]=[CH:4][N:3]=1.[CH3:37]NC>>[CH3:37][N:18]([CH2:17][C@H:14]1[CH2:13][CH2:12][C@H:11]([C:10]2[N:6]3[C:7]([C:2]([NH2:1])=[N:3][CH:4]=[N:5]3)=[C:8]([C:24]3[CH:29]=[CH:28][C:27]([O:30][C:31]4[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=4)=[CH:26][CH:25]=3)[N:9]=2)[CH2:16][CH2:15]1)[CH3:19]

Participants

Reactant 2

HCID 674Dimethylamine

HCID 178483777HCID 178483777, compound

Product 1

HCID 178483622HCID 178483622, compound

Procedure

Prepared according to the procedure analogous to that described above for trans-N-{4-[4-Amino-5-(4-phenoxy-phenyl)-imidazo[5,1-f][1,2,4]triazin-7-yl]-cyclohexylmethyl}-N′,N′-dimethyl-ethane-1,2-diamine, except using dimethylamine.

Workup

customPrepared

Sources & evidence

ORD record: ord-5fda95925cad4fa5807bde97add60fcc
Source dataset: uspto-grants-2013_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08481733B2

Reaction notes

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