Ethanolamine → HCID 178508822, compound

HRID 449085Notes

Reaction equation

HRID 449085 reaction equation
[NH2:1][C:2]1[C:7]2=[C:8]([C:24]3[CH:29]=[CH:28][C:27]([O:30][C:31]4[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=4)=[CH:26][CH:25]=3)[N:9]=[C:10]([C@H:11]3[CH2:16][CH2:15][C@H:14]([CH2:17][NH:18][CH2:19][CH2:20]N(C)C)[CH2:13][CH2:12]3)[N:6]2[N:5]=[CH:4][N:3]=1.NCC[OH:40]>>[NH2:1][C:2]1[C:7]2=[C:8]([C:24]3[CH:25]=[CH:26][C:27]([O:30][C:31]4[CH:32]=[CH:33][CH:34]=[CH:35][CH:36]=4)=[CH:28][CH:29]=3)[N:9]=[C:10]([C@H:11]3[CH2:12][CH2:13][C@H:14]([CH2:17][NH:18][CH2:19][CH2:20][OH:40])[CH2:15][CH2:16]3)[N:6]2[N:5]=[CH:4][N:3]=1

Participants

3

Reactant 2

HCID 700EthanolamineHCID 178483777HCID 178483777, compound

Product 1

HCID 178508822HCID 178508822, compound

Procedure

Prepared according to the procedure analogous to that described above for trans-N-{4-[4-Amino-5-(4-phenoxy-phenyl)-imidazo[5,1-f][1,2,4]triazin-7-yl]-cyclohexylmethyl}-N′,N′-dimethyl-ethane-1,2-diamine, except using 2-amino-ethanol.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-683ff7fd6bdb488f8ad8e4a0af0ee3ba
Source dataset
uspto-grants-2013_07
Patent number
US08481733B2

Reaction notes

Loading…