Oxygen → HCID 66915608, compound

Participants

Reaction Steps

Into a 100 mL round bottom flask was added 4-bromophenol (2.19 g, 12.7 mmol), 2,6-difluorophenylboronic acid (1.00 g, 6.33 mmol), cupric acetate (1.4 g, 7.70 mmol) and DCM (50 mL). TEA (4.0 mL, 29.0 mmol) was then added followed by 4 A° molecular sieves and the reaction mixture was stirred at rt for 48 h with an air balloon to supply oxygen. Purification by flash column chromatography using 5% EtOAc in hexanes afforded the title compound as a colorless oil.

Provenance & Evidence