5-Bromo-1-phenyl-1H-benzoimidazole → 1-Phenyl-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-benzoimidazole

HRID 449116Notes

Reaction equation

HRID 449116 reaction equation
Br[C:2]1[CH:16]=[CH:15][C:5]2[N:6]([C:9]3[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=3)[CH:7]=[N:8][C:4]=2[CH:3]=1.[CH3:17][C:18]1([CH3:39])[C:22]([CH3:24])([CH3:23])[O:21][B:20](C2C=CC(OC3C=CC=CC=3)=CC=2C)[O:19]1>>[C:9]1([N:6]2[C:5]3[CH:15]=[CH:16][C:2]([B:20]4[O:21][C:22]([CH3:24])([CH3:23])[C:18]([CH3:39])([CH3:17])[O:19]4)=[CH:3][C:4]=3[N:8]=[CH:7]2)[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1

Participants

3

Reactant 2

HCID 120181715-Bromo-1-phenyl-1H-benzoimidazoleHCID 227364244,4,5,5-Tetramethyl-2-(2-methyl-4-phenoxyphenyl)-1,3,2-dioxaborolane

Product 1

HCID 120181731-Phenyl-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-benzoimidazole

Procedure

Prepared from 5-bromo-1-phenyl-1H-benzoimidazole according to general Method I for borylation described above for preparation of 4,4,5,5-tetramethyl-2-(2-methyl-4-phenoxy-phenyl)-[1,3,2]dioxaborolane.

Sources & evidence

ORD record
ord-348126e86d0a48a1a193f2be5e14b04e
Source dataset
uspto-grants-2013_07
Patent number
US08481733B2

Reaction notes

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