Tetrahydro-2H-pyran-2-carbaldehyde → (4-Chloro-phenyl)-(tetrahydro-pyran-2-yl)-methanol

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of tetrahydro-pyran-2-carbaldehyde (114.00 mg, 1.00 mmol) in THF (10 mL) was added 4-chlorophenylmagnesium bromide (1.0 M in diethyl ether, 1.5 mL, 1.50 mmol) at −78° C. The mixture was stirred at −78° C. for 2 hrs. The solvent was then removed under reduced pressure and the resulting residue was purified by a flash chromatography (eluting with 20% AcOEt in Hexane).

Provenance & Evidence