反应详情

To a stirred mixture of 2-chloro-phenylboronic acid (1.54 g, 9.85 mmol) and 4-bromo-2-methoxyphenol (1.00 g, 4.92 mmol) in DCM (50.00 mL) was added cupric acetate (1.34 g, 7.39 mmol), powdered 4 A molecular sieves and TEA (3.43 mL, 24.6 mmol) at rt. The resulting mixture was then stirred at rt for 48 h at ambient atmosphere. The solvent was then removed under reduced pressure and the resulting residue was purified by flash chromatography (5% EtOAc in hexane).

1. customat rt
2. customThe solvent was then removed under reduced pressure
3. customthe resulting residue was purified by flash chromatography (5% EtOAc in hexane)