Hydrochloric Acid → (R)-2-Amino-N-(3,5-dichloro-4-fluoro-phenyl)-propionamide

Participants

Reaction Steps

To a solution of hydrochloric acid (12 M, 266 mL, 3.19 mol) in water (272 mL) and MeOH (135 mL) was added a solution of crude [(R)-1-(3,5-dichloro-4-fluoro-phenylcarbamoyl)-ethyl]-carbamic acid tert-butyl ester (208.6 g, max. 594 mmol) in MeOH (600 mL) via an addition funnel over 30 min CH2Cl2 (300 mL) was then added and the reaction mixture was stirred at room temperature overnight. An additional portion of HCl (12M, 100 mL) was added and stirring was continued for another 20 h. The volatile solvents were removed in vacuo and the remaining aqueous mixture was cooled to −15 to −20° C. Toluene (400 mL) was added followed by the addition of NaOH solution (50% aqueous, 300 mL), which was added at a rate to keep the internal temperature below 25° C. The layers were separated and the aqueous layer was extracted with toluene (2×1 L). The combined organic layers were dried with Na2SO4 and concentrated to give 158.3 g of the title compound as a dark brown oil that solidified slowly in the freezer, m/z 251.1 [M+H]+. This crude material was used without further purification.

Provenance & Evidence