Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sulfamic Acid | HCID 5987 | — |
| Reactant | P-Anisidine | HCID 7732 | — |
| Reactant | 7-(3,5-Dimethyl-4-isoxazolyl)-5-methyl-1,2,4-benzotriazin-3-amine | HCID 59837764 | — |
| Product | HCID 59837602 | HCID 59837602 | 32.1% |
Reaction Steps
The mixture of 5-methyl-7-(3,5-dimethylisoxazol-4-yl)benzo[e][1,2,4]triazin-3-amine (compound 7 on scheme (CXXVIII)) (107 mg, 0.42 mmol), sulfamic acid (81.4 mg, 0.84 mmol), and 4-methoxybenzenamine 8 (774 mg, 6.3 mmol) was heated at 180° C. overnight. The product was purified by chromatography (SiO2/CH2Cl2) and the title product (48.7 mg, 32%) was obtained as a yellow solid. 1H NMR (CD2Cl2): δ 2.34 (s, 3H); 2.49 (s, 3H); 2.70 (s, 3H); 3.84 (s, 3H); 6.99 (d, J=8.9 Hz, 2H); 7.57 (s, 1H); 7.83 (d, J=8.9 Hz, 2H); 8.03 (s, 1H); 8.10 (br, 1H). MS (ESI+): m/z=362.1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08481536B2 |
|---|
| Source dataset | uspto-grants-2013_07 |
|---|
| ORD ID | ord-7a74f609f3b04243a72e10c9d9fa06d3 |
|---|
| Source note | uspto-grants-2013_07 |
|---|
