反应详情

温度

65 °C

To a solution of quinoline-6-carboxylic acid (183 g, 1.06 mol) in methanol (1 lit.), thionyl chloride (150.7 g, 1.2 mol) was added dropwise at 0° C. and then stirred at 65° C. for 12 h. The reaction mixture was concentrated and to the residue dichloromethane and aqueous sodium carbonate solutions were added. The organic layer was dried with sodium sulphate and concentrated to afford the title compound as a brown solid (150 g, 75%).

1. concentrationThe reaction mixture was concentrated and to the residue dichloromethane and aqueous sodium carbonate solutions
2. additionwere added
3. dry with materialThe organic layer was dried with sodium sulphate
4. concentrationconcentrated