HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phenylacetyl chloride → 4-(4-Methylpiperazin-1-yl)-6-[2-(phenylacetyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyrimidin-2-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phenylacetyl chloride | HCID 7679 | — |
| Reactant | 4-(4-methylpiperazin-1-yl)-6-(1,2,3,4-tetrahydroisoquinolin-7-yl)pyrimidin-2-amine HCl salt | HCID 67541489 | — |
| Product | 4-(4-Methylpiperazin-1-yl)-6-[2-(phenylacetyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyrimidin-2-amine | HCID 49779513 | — |
Reaction Steps
This compound was prepared from benzeneacetyl chloride and 4-(4-methylpiperazin-1-yl)-6-(1,2,3,4-tetrahydroisoquinolin-7-yl)pyrimidin-2-amine HCl salt using procedures analogous to those for Example 2. Analytic LCMS (M+H)+: m/z=443.4.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08481732B2 |
| Source dataset | uspto-grants-2013_07 |
| ORD ID | ord-36f02e5c83ef4694a222b88965ee6b6e |
| Source note | uspto-grants-2013_07 |