HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Pyrrolidinecarbonyl chloride → 4-(4-Methylpiperazin-1-yl)-6-[2-(pyrrolidin-1-ylcarbonyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyrimidin-2-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Pyrrolidinecarbonyl chloride | HCID 70937 | — |
| Reactant | 4-(4-methylpiperazin-1-yl)-6-(1,2,3,4-tetrahydroisoquinolin-7-yl)pyrimidin-2-amine HCl salt | HCID 67541489 | — |
| Product | 4-(4-Methylpiperazin-1-yl)-6-[2-(pyrrolidin-1-ylcarbonyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyrimidin-2-amine | HCID 49779515 | — |
Reaction Steps
This compound was prepared from 1-pyrrolidinecarbonyl chloride and 4-(4-methylpiperazin-1-yl)-6-(1,2,3,4-tetrahydroisoquinolin-7-yl)pyrimidin-2-amine HCl salt using procedures analogous to those for Example 2. Analytic LCMS (M+H)+: m/z=422.4.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08481732B2 |
| Source dataset | uspto-grants-2013_07 |
| ORD ID | ord-867830c26b3841e5b735b62c47137a35 |
| Source note | uspto-grants-2013_07 |