Benzoyl chloride, 3-chloro- → HCID 49779518, compound

HRID 449341Notes

Reaction equation

HRID 449341 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][CH:10]=1)[C:5](Cl)=[O:6].Cl.[CH3:12][N:13]1[CH2:18][CH2:17][N:16]([C:19]2[CH:24]=[C:23]([C:25]3[CH:34]=[C:33]4[C:28]([CH2:29][CH2:30][NH:31][CH2:32]4)=[CH:27][CH:26]=3)[N:22]=[C:21]([NH2:35])[N:20]=2)[CH2:15][CH2:14]1>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][CH:10]=1)[C:5]([N:31]1[CH2:30][CH2:29][C:28]2[C:33](=[CH:34][C:25]([C:23]3[CH:24]=[C:19]([N:16]4[CH2:15][CH2:14][N:13]([CH3:12])[CH2:18][CH2:17]4)[N:20]=[C:21]([NH2:35])[N:22]=3)=[CH:26][CH:27]=2)[CH2:32]1)=[O:6]

Participants

3

Reactant 2

HCID 69252Benzoyl chloride, 3-chloro-HCID 675414894-(4-methylpiperazin-1-yl)-6-(1,2,3,4-tetrahydroisoquinolin-7-yl)pyrimidin-2-amine HCl salt

Product 1

HCID 49779518HCID 49779518, compound

Procedure

This compound was prepared by using procedures analogous to those described for the synthesis of Example 2 starting from 3-chlorobenzoyl chloride (Lancaster, Cat. #L01191) and 4-(4-methylpiperazin-1-yl)-6-(1,2,3,4-tetrahydroisoquinolin-7-yl)pyrimidin-2-amine HCl salt. Analytic LCMS (M+H)+: m/z=463.3/465.3.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-3f419217096d476f8ef0a69363b4cecc
Source dataset
uspto-grants-2013_07
Patent number
US08481732B2

Reaction notes

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