Phosgene → HCID 59496735, compound

HRID 449345Notes

Reaction equation

HRID 449345 reaction equation
[NH2:1][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][N:3]=1.[C:10](Cl)(Cl)=[O:11].Cl.[CH3:15][N:16]1[CH2:21][CH2:20][N:19]([C:22]2[CH:27]=[C:26]([C:28]3[CH:37]=[C:36]4[C:31]([CH2:32][CH2:33][NH:34][CH2:35]4)=[CH:30][CH:29]=3)[N:25]=[C:24]([NH2:38])[N:23]=2)[CH2:18][CH2:17]1>>[NH2:38][C:24]1[N:25]=[C:26]([C:28]2[CH:37]=[C:36]3[C:31]([CH2:32][CH2:33][N:34]([C:10]([NH:1][C:2]4[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][N:3]=4)=[O:11])[CH2:35]3)=[CH:30][CH:29]=2)[CH:27]=[C:22]([N:19]2[CH2:18][CH2:17][N:16]([CH3:15])[CH2:21][CH2:20]2)[N:23]=1

Participants

4

Reactant 3

HCID 6371PhosgeneHCID 8182602-Amino-5-cyanopyridineHCID 675414894-(4-methylpiperazin-1-yl)-6-(1,2,3,4-tetrahydroisoquinolin-7-yl)pyrimidin-2-amine HCl salt

Product 1

HCID 59496735HCID 59496735, compound

Procedure

This compound was prepared by using procedures analogous to those described for the synthesis of Example 40 starting from 6-aminonicotinonitrile (Aldrich, Cat. #637475), phosgene and 4-(4-methylpiperazin-1-yl)-6-(1,2,3,4-tetrahydroisoquinolin-7-yl)pyrimidin-2-amine HCl salt. Analytic LCMS (M+H)+: m/z=470.2.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-58558383e1e74432a0e729d1a16e90bd
Source dataset
uspto-grants-2013_07
Patent number
US08481732B2

Reaction notes

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