HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosgene → HCID 67542284, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosgene | HCID 6371 | — |
| Reactant | ethyl (1R,2S)-2-aminocyclohexane-1-carboxylate hydrochloride | HCID 2724641 | — |
| Reactant | 4-(4-methylpiperazin-1-yl)-6-(1,2,3,4-tetrahydroisoquinolin-7-yl)pyrimidin-2-amine HCl salt | HCID 67541489 | — |
| Product | HCID 67542284 | HCID 67542284 | — |
Reaction Steps
This compound was prepared by using procedures analogous to those described for the synthesis of Example 40 starting from ethyl cis-2-aminocyclohexanecarboxylate hydrochloride (Acros Organics, Cat. #26564), phosgene and 4-(4-methylpiperazin-1-yl)-6-(1,2,3,4-tetrahydroisoquinolin-7-yl)pyrimidin-2-amine HCl salt. Analytic LCMS (M+H)+: m/z=522.3.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08481732B2 |
| Source dataset | uspto-grants-2013_07 |
| ORD ID | ord-8bc8d9b7693d4473a57ffd247962cf71 |
| Source note | uspto-grants-2013_07 |