HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,2-Difluoro-2-phenylacetic acid → 4-{2-[Difluoro(phenyl)acetyl]-1,2,3,4-tetrahydroisoquinolin-7-yl}-6-(4-methylpiperazin-1-yl)pyrimidin-2-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,2-Difluoro-2-phenylacetic acid | HCID 726153 | — |
| Reactant | 4-(4-methylpiperazin-1-yl)-6-(1,2,3,4-tetrahydroisoquinolin-7-yl)pyrimidin-2-amine HCl salt | HCID 67541489 | — |
| Product | 4-{2-[Difluoro(phenyl)acetyl]-1,2,3,4-tetrahydroisoquinolin-7-yl}-6-(4-methylpiperazin-1-yl)pyrimidin-2-amine | HCID 59496688 | — |
Reaction Steps
This compound was prepared by using procedures analogous to those described for the synthesis of Example 41 starting from difluoro(phenyl)acetic acid (Matrix Scientific, Cat. #018321) and 4-(4-methylpiperazin-1-yl)-6-(1,2,3,4-tetrahydroisoquinolin-7-yl)pyrimidin-2-amine HCl salt. Analytic LCMS (M+H)+: m/z=479.2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08481732B2 |
| Source dataset | uspto-grants-2013_07 |
| ORD ID | ord-b2ebd3b14e654683a59133785ea903d1 |
| Source note | uspto-grants-2013_07 |