HRID449381

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID7917

Isopropyl chloroformate

C4H7ClO2

结构：CN1CCN(c2cc(-c3ccc4c(c3)CN(C(=O)OC3CCNCC3)CC4)nc(N)n2)CC1.Cl

HCID67541330

未命名化合物

PRODUCTS

生成物

结构：CC(C)OC(=O)N1CCC(OC(=O)N2CCc3ccc(-c4cc(N5CCN(C)CC5)nc(N)n4)cc3C2)CC1

HCID59496594

未命名化合物

PROCEDURE

实验过程

This compound was prepared by using procedures analogous to those described for the synthesis of Example 67, Step 4 starting from isopropyl chloroformate and piperidin-4-yl 7-[2-amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]-3,4-dihydroisoquinoline-2(1H)-carboxylate HCl salt. Analytic LCMS (M+H)+: m/z=538.3.

WORKUP

后处理

customThis compound was prepared

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-80c5650962a044e1b26a4bcbea5e1053
来源数据集: uspto-grants-2013_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08481732B2
来源说明: uspto-grants-2013_07

反应 SMILES

Cl[C:2]([O:4][CH:5]([CH3:7])[CH3:6])=[O:3].Cl.[NH2:9][C:10]1[N:15]=[C:14]([C:16]2[CH:25]=[C:24]3[C:19]([CH2:20][CH2:21][N:22]([C:26]([O:28][CH:29]4[CH2:34][CH2:33][NH:32][CH2:31][CH2:30]4)=[O:27])[CH2:23]3)=[CH:18][CH:17]=2)[CH:13]=[C:12]([N:35]2[CH2:40][CH2:39][N:38]([CH3:41])[CH2:37][CH2:36]2)[N:11]=1>>[NH2:9][C:10]1[N:15]=[C:14]([C:16]2[CH:25]=[C:24]3[C:19]([CH2:20][CH2:21][N:22]([C:26]([O:28][CH:29]4[CH2:34][CH2:33][N:32]([C:2]([O:4][CH:5]([CH3:7])[CH3:6])=[O:3])[CH2:31][CH2:30]4)=[O:27])[CH2:23]3)=[CH:18][CH:17]=2)[CH:13]=[C:12]([N:35]2[CH2:40][CH2:39][N:38]([CH3:41])[CH2:37][CH2:36]2)[N:11]=1