HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclopentyl Isocyanate → 1-[(Cyclopentylamino)carbonyl]piperidin-4-yl 7-[2-amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]-3,4-dihydroisoquinoline-2(1h)-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclopentyl Isocyanate | HCID 643500 | — |
| Reactant | piperidin-4-yl 7-[2-amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]-3,4-dihydroisoquinoline-2(1H)-carboxylate HCl salt | HCID 67541330 | — |
| Product | 1-[(Cyclopentylamino)carbonyl]piperidin-4-yl 7-[2-amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]-3,4-dihydroisoquinoline-2(1h)-carboxylate | HCID 59496667 | — |
Reaction Steps
This compound was prepared by using procedures analogous to those described for the synthesis of Example 67, Step 4 starting from isocyanatocyclopentane and piperidin-4-yl 7-[2-amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]-3,4-dihydroisoquinoline-2(1H)-carboxylate HCl salt. Analytic LCMS (M+H)+: m/z=563.3.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08481732B2 |
| Source dataset | uspto-grants-2013_07 |
| ORD ID | ord-72c1a65ee76b452c999926d2bed70662 |
| Source note | uspto-grants-2013_07 |