Benzoyl chloride → HCID 67541219, compound

HRID 449387Notes

Reaction equation

[C:1](Cl)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl.[CH3:11][N:12]1[CH2:17][CH2:16][N:15]([C:18]2[CH:23]=[C:22]([C:24]3[CH:33]=[C:32]4[C:27]([CH2:28][CH2:29][N:30]([C:34](=[O:42])[CH2:35][CH:36]5[CH2:41][CH2:40][NH:39][CH2:38][CH2:37]5)[CH2:31]4)=[CH:26][CH:25]=3)[N:21]=[C:20]([NH2:43])[N:19]=2)[CH2:14][CH2:13]1>>[C:1]([N:39]1[CH2:38][CH2:37][CH:36]([CH2:35][C:34]([N:30]2[CH2:29][CH2:28][C:27]3[C:32](=[CH:33][C:24]([C:22]4[CH:23]=[C:18]([N:15]5[CH2:16][CH2:17][N:12]([CH3:11])[CH2:13][CH2:14]5)[N:19]=[C:20]([NH2:43])[N:21]=4)=[CH:25][CH:26]=3)[CH2:31]2)=[O:42])[CH2:41][CH2:40]1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

Reactant 2

HCID 7412Benzoyl chloride

HCID 67541747HCID 67541747, compound

Product 1

HCID 67541219HCID 67541219, compound

Procedure

This compound was prepared by using procedures analogous to those described for the synthesis of Example 71, Step 4 starting from benzoyl chloride (Alfa Aesar, Cat. #A14107) and 4-(4-methylpiperazin-1-yl)-6-[2-(piperidin-4-ylacetyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyrimidin-2-amine HCl salt. Analytic LCMS (M+H)+: m/z=554.3.

Workup

customThis compound was prepared

Sources & evidence

ORD record: ord-935ca8ecf129473bb8d56ba7a10fb184
Source dataset: uspto-grants-2013_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08481732B2

Reaction notes

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