4-Chloro-6-(4-methylpiperazin-1-yl)pyrimidin-2-amine → HCID 59496585, compound

HRID 449395Notes

Reaction equation

HRID 449395 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1B1OC(C)(C)C(C)(C)O1)[CH2:8][N:7]([C:21]([O:23][C:24]([CH3:27])([CH3:26])[CH3:25])=[O:22])[CH2:6][CH2:5]2.Cl[C:29]1[CH:34]=[C:33]([N:35]2[CH2:40][CH2:39][N:38]([CH3:41])[CH2:37][CH2:36]2)[N:32]=[C:31]([NH2:42])[N:30]=1>>[NH2:42][C:31]1[N:30]=[C:29]([C:11]2[CH:10]=[C:9]3[C:4]([CH2:5][CH2:6][N:7]([C:21]([O:23][C:24]([CH3:25])([CH3:27])[CH3:26])=[O:22])[CH2:8]3)=[CH:3][C:2]=2[CH3:1])[CH:34]=[C:33]([N:35]2[CH2:40][CH2:39][N:38]([CH3:41])[CH2:37][CH2:36]2)[N:32]=1

Participants

3

Reactant 2

HCID 14845194-Chloro-6-(4-methylpiperazin-1-yl)pyrimidin-2-amineHCID 59496629HCID 59496629, compound

Product 1

HCID 59496585HCID 59496585, compound

Procedure

This compound was prepared by using procedures analogous to those described for the synthesis of Example 75, Step 4 starting from tert-butyl 6-methyl-7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydroisoquinoline-2(1H)-carboxylate and 4-chloro-6-(4-methylpiperazin-1-yl)pyrimidin-2-amine Analytic LCMS (M+H)+: m/z=439.2.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-b74777d583014af9ad6bf2b2f03db667
Source dataset
uspto-grants-2013_07
Patent number
US08481732B2

Reaction notes

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