Cyclohexyl isocyanate → HCID 59496668, compound

HRID 449398Notes

Reaction equation

HRID 449398 reaction equation
Cl.[CH3:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[C:13]1[CH:18]=[C:17]([N:19]3[CH2:24][CH2:23][N:22]([CH3:25])[CH2:21][CH2:20]3)[N:16]=[C:15]([NH2:26])[N:14]=1)[CH2:9][NH:8][CH2:7][CH2:6]2.[CH:27]1([N:33]=[C:34]=[O:35])[CH2:32][CH2:31][CH2:30][CH2:29][CH2:28]1>>[NH2:26][C:15]1[N:14]=[C:13]([C:12]2[CH:11]=[C:10]3[C:5]([CH2:6][CH2:7][N:8]([C:34]([NH:33][CH:27]4[CH2:32][CH2:31][CH2:30][CH2:29][CH2:28]4)=[O:35])[CH2:9]3)=[CH:4][C:3]=2[CH3:2])[CH:18]=[C:17]([N:19]2[CH2:24][CH2:23][N:22]([CH3:25])[CH2:21][CH2:20]2)[N:16]=1

Participants

3

Reactant 2

HCID 18502Cyclohexyl isocyanateHCID 67541974HCID 67541974, compound

Product 1

HCID 59496668HCID 59496668, compound

Procedure

This compound was prepared by using procedures analogous to those described for the synthesis of Example 77, Step 6 starting from 4-(6-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)-6-(4-methylpiperazin-1-yl)pyrimidin-2-amine HCl salt, and cyclohexylisocyanate. Analytic LCMS (M+H)+: m/z=464.2.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-85e2405b32e34ea88570d8745cab3f82
Source dataset
uspto-grants-2013_07
Patent number
US08481732B2

Reaction notes

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