HCID 15343685, compound → HCID 49779646, compound

HRID 449400Notes

Reaction equation

HRID 449400 reaction equation
[C:1](=[O:18])([O:12][CH:13]1[CH2:17][CH2:16][O:15][CH2:14]1)OC1C=CC([N+]([O-])=O)=CC=1.Cl.[CH3:20][N:21]1[CH2:26][CH2:25][N:24]([C:27]2[CH:32]=[C:31]([C:33]3[CH:42]=[C:41]4[C:36]([CH2:37][CH2:38][NH:39][CH2:40]4)=[CH:35][CH:34]=3)[N:30]=[C:29]([NH2:43])[N:28]=2)[CH2:23][CH2:22]1>>[NH2:43][C:29]1[N:30]=[C:31]([C:33]2[CH:42]=[C:41]3[C:36]([CH2:37][CH2:38][N:39]([C:1]([O:12][CH:13]4[CH2:17][CH2:16][O:15][CH2:14]4)=[O:18])[CH2:40]3)=[CH:35][CH:34]=2)[CH:32]=[C:27]([N:24]2[CH2:23][CH2:22][N:21]([CH3:20])[CH2:26][CH2:25]2)[N:28]=1

Participants

3

Reactant 2

HCID 15343685HCID 15343685, compoundHCID 675414894-(4-methylpiperazin-1-yl)-6-(1,2,3,4-tetrahydroisoquinolin-7-yl)pyrimidin-2-amine HCl salt

Product 1

HCID 49779646HCID 49779646, compound

Procedure

This compound was prepared by using procedures analogous to those described for the synthesis of Example 67, Step 2 starting from 4-nitrophenyl tetrahydrofuran-3-yl carbonate and 4-(4-methylpiperazin-1-yl)-6-(1,2,3,4-tetrahydroisoquinolin-7-yl)pyrimidin-2-amine HCl salt. Analytic LCMS (M+H)+: m/z=439.4.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-a7ee2d0153864c62ba30c34a8cc09e29
Source dataset
uspto-grants-2013_07
Patent number
US08481732B2

Reaction notes

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