Phosgene → 7-[2-Amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]-N-(2,3-dihydro-1H-inden-1-yl)-3,4-dihydroisoquinoline-2(1H)-carboxamide

Participants

Role	Name	HCID	Charge
Reactant	Phosgene	HCID 6371	—
Reactant	(+-)-1-Aminoindan	HCID 123445	—
Reactant	4-(4-methylpiperazin-1-yl)-6-(1,2,3,4-tetrahydroisoquinolin-7-yl)pyrimidin-2-amine HCl salt	HCID 67541489	—
Product	7-[2-Amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]-N-(2,3-dihydro-1H-inden-1-yl)-3,4-dihydroisoquinoline-2(1H)-carboxamide	HCID 49779647	—

Reaction Steps

This compound was prepared by using procedures analogous to those described for the synthesis of Example 40 starting from 2,3-dihydro-1H-inden-1-amine (Aldrich, Cat. #A59506), phosgene and 4-(4-methylpiperazin-1-yl)-6-(1,2,3,4-tetrahydroisoquinolin-7-yl)pyrimidin-2-amine HCl salt. Analytic LCMS (M+H)+: m/z=484.2.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08481732B2
Source dataset	uspto-grants-2013_07
ORD ID	ord-520cbaf7c91141348355052017d54e7f
Source note	uspto-grants-2013_07