Phosgene → 7-[2-Amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-3,4-dihydroisoquinoline-2(1H)-carboxamide

Participants

Role	Name	HCID	Charge
Reactant	Phosgene	HCID 6371	—
Reactant	1,2,3,4-Tetrahydro-1-naphthylamine	HCID 18066	—
Reactant	4-(4-methylpiperazin-1-yl)-6-(1,2,3,4-tetrahydroisoquinolin-7-yl)pyrimidin-2-amine HCl salt	HCID 67541489	—
Product	7-[2-Amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-3,4-dihydroisoquinoline-2(1H)-carboxamide	HCID 49779648	—

Reaction Steps

This compound was prepared by using procedures analogous to those described for the synthesis of Example 40 starting from 1,2,3,4-tetrahydronaphthalen-1-amine (Aldrich, Cat. #247820), phosgene and 4-(4-methylpiperazin-1-yl)-6-(1,2,3,4-tetrahydroisoquinolin-7-yl)pyrimidin-2-amine HCl salt. Analytic LCMS (M+H)+: m/z=498.3.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08481732B2
Source dataset	uspto-grants-2013_07
ORD ID	ord-4d775346e1f24a4881e18a0a5ddb4683
Source note	uspto-grants-2013_07