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HRID449405

反应详情

EQUATION

反应方程式

HRID 449405 的结构方程式

REACTANTS

反应物

3
结构：O=C(Cl)Cl
HCID6371

Phosgene

CCl2O

结构：Cc1ccc(S(=O)(=O)O)cc1.N[C@@H]1CCOC1
HCID14243169

4-Methylbenzene-1-sulfonic acid--(3R)-oxolan-3-amine (1/1)

C11H17NO4S

结构：CN1CCN(c2cc(-c3ccc4c(c3)CNCC4)nc(N)n2)CC1.Cl
HCID67541489

未命名化合物

PRODUCTS

生成物

1
结构：CN1CCN(c2cc(-c3ccc4c(c3)CN(C(=O)N[C@@H]3CCOC3)CC4)nc(N)n2)CC1
HCID59496754

未命名化合物

PROCEDURE

实验过程

This compound was prepared by using procedures analogous to those described for the synthesis of Example 40 starting from (3R)-tetrahydrofuran-3-amine 4-methylbenzenesulfonate (Fluka, Cat. #09440), phosgene and 4-(4-methylpiperazin-1-yl)-6-(1,2,3,4-tetrahydroisoquinolin-7-yl)pyrimidin-2-amine HCl salt. Analytic LCMS (M+H)+: m/z=438.3.

WORKUP

后处理

  1. customThis compound was prepared