Phosgene → HCID 67541517, compound

HRID 449407Notes

Reaction equation

HRID 449407 reaction equation
Cl.[CH2:2]([O:4][C@H:5]1[CH2:10][CH2:9][CH2:8][CH2:7][C@H:6]1[NH2:11])[CH3:3].[C:12](Cl)(Cl)=[O:13].Cl.[CH3:17][N:18]1[CH2:23][CH2:22][N:21]([C:24]2[CH:29]=[C:28]([C:30]3[CH:39]=[C:38]4[C:33]([CH2:34][CH2:35][NH:36][CH2:37]4)=[CH:32][CH:31]=3)[N:27]=[C:26]([NH2:40])[N:25]=2)[CH2:20][CH2:19]1>>[NH2:40][C:26]1[N:27]=[C:28]([C:30]2[CH:39]=[C:38]3[C:33]([CH2:34][CH2:35][N:36]([C:12]([NH:11][C@@H:6]4[CH2:7][CH2:8][CH2:9][CH2:10][C@@H:5]4[O:4][CH2:2][CH3:3])=[O:13])[CH2:37]3)=[CH:32][CH:31]=2)[CH:29]=[C:24]([N:21]2[CH2:20][CH2:19][N:18]([CH3:17])[CH2:23][CH2:22]2)[N:25]=1

Participants

4

Reactant 3

HCID 6371PhosgeneHCID 675414894-(4-methylpiperazin-1-yl)-6-(1,2,3,4-tetrahydroisoquinolin-7-yl)pyrimidin-2-amine HCl saltHCID 67541601HCID 67541601, compound

Product 1

HCID 67541517HCID 67541517, compound

Procedure

This compound was prepared by using procedures analogous to those described for the synthesis of Example 55, Step 3 starting from cis-2-ethoxycyclohexanamine HCl salt, phosgene and 4-(4-methylpiperazin-1-yl)-6-(1,2,3,4-tetrahydroisoquinolin-7-yl)pyrimidin-2-amine HCl salt. Analytic LCMS (M+H)+: m/z=494.3.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-05351458823e4162b933bb61cbf813d1
Source dataset
uspto-grants-2013_07
Patent number
US08481732B2

Reaction notes

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