Cyclohexyl isocyanate → HCID 59496557, compound

HRID 449417Notes

Reaction equation

HRID 449417 reaction equation
[CH:1]1([N:7]=[C:8]=[O:9])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.Cl.[CH3:11][N:12]1[CH2:17][CH2:16][N:15]([C:18]2[CH:23]=[C:22]([C:24]3[CH:33]=[C:32]4[C:27]([CH2:28][CH2:29][NH:30][CH2:31]4)=[CH:26][CH:25]=3)[N:21]=[C:20]([NH2:34])[N:19]=2)[CH2:14][CH2:13]1>>[NH2:34][C:20]1[N:21]=[C:22]([C:24]2[CH:33]=[C:32]3[C:27]([CH2:28][CH2:29][N:30]([C:8]([NH:7][CH:1]4[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]4)=[O:9])[CH2:31]3)=[CH:26][CH:25]=2)[CH:23]=[C:18]([N:15]2[CH2:14][CH2:13][N:12]([CH3:11])[CH2:17][CH2:16]2)[N:19]=1

Participants

3

Reactant 2

HCID 18502Cyclohexyl isocyanateHCID 675414894-(4-methylpiperazin-1-yl)-6-(1,2,3,4-tetrahydroisoquinolin-7-yl)pyrimidin-2-amine HCl salt

Product 1

HCID 59496557HCID 59496557, compound

Procedure

This compound was prepared by using procedures analogous to those described for the synthesis of Example 5 starting from cyclohexylisocyanate and 4-(4-methylpiperazin-1-yl)-6-(1,2,3,4-tetrahydroisoquinolin-7-yl)pyrimidin-2-amine HCl salt. Analytic LCMS (M+H)+: m/z=450.2.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-59dabdabfc8b4afd83586b0da6a35cb0
Source dataset
uspto-grants-2013_07
Patent number
US08481732B2

Reaction notes

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