Isovaleryl chloride → HCID 59496658, compound

HRID 449422Notes

Reaction equation

HRID 449422 reaction equation
[CH3:1][CH:2]([CH3:7])[CH2:3][C:4](Cl)=[O:5].Cl.[CH3:9][N:10]1[CH2:15][CH2:14][N:13]([C:16]2[CH:21]=[C:20]([C:22]3[CH:31]=[C:30]4[C:25]([CH2:26][CH2:27][NH:28][CH2:29]4)=[CH:24][CH:23]=3)[N:19]=[C:18]([NH2:32])[N:17]=2)[CH2:12][CH2:11]1>>[CH3:1][CH:2]([CH3:7])[CH2:3][C:4]([N:28]1[CH2:27][CH2:26][C:25]2[C:30](=[CH:31][C:22]([C:20]3[CH:21]=[C:16]([N:13]4[CH2:12][CH2:11][N:10]([CH3:9])[CH2:15][CH2:14]4)[N:17]=[C:18]([NH2:32])[N:19]=3)=[CH:23][CH:24]=2)[CH2:29]1)=[O:5]

Participants

3

Reactant 2

HCID 66054Isovaleryl chlorideHCID 675414894-(4-methylpiperazin-1-yl)-6-(1,2,3,4-tetrahydroisoquinolin-7-yl)pyrimidin-2-amine HCl salt

Product 1

HCID 59496658HCID 59496658, compound

Procedure

This compound was prepared by using procedures analogous to those described for the synthesis of Example 2 starting from 3-methylbutanoyl chloride (Aldrich, Cat. #157422) and 4-(4-methylpiperazin-1-yl)-6-(1,2,3,4-tetrahydroisoquinolin-7-yl)pyrimidin-2-amine HCl salt. Analytic LCMS (M+H)+: m/z=409.2.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-41c091b030354750be1de9ffabadc6b4
Source dataset
uspto-grants-2013_07
Patent number
US08481732B2

Reaction notes

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