Benzenepropanoyl chloride → HCID 59496704, compound

HRID 449423Notes

Reaction equation

HRID 449423 reaction equation
[CH:1]1[CH:6]=[CH:5][C:4]([CH2:7][CH2:8][C:9](Cl)=[O:10])=[CH:3][CH:2]=1.Cl.[CH3:13][N:14]1[CH2:19][CH2:18][N:17]([C:20]2[CH:25]=[C:24]([C:26]3[CH:35]=[C:34]4[C:29]([CH2:30][CH2:31][NH:32][CH2:33]4)=[CH:28][CH:27]=3)[N:23]=[C:22]([NH2:36])[N:21]=2)[CH2:16][CH2:15]1>>[CH3:13][N:14]1[CH2:15][CH2:16][N:17]([C:20]2[CH:25]=[C:24]([C:26]3[CH:35]=[C:34]4[C:29]([CH2:30][CH2:31][N:32]([C:9](=[O:10])[CH2:8][CH2:7][C:4]5[CH:5]=[CH:6][CH:1]=[CH:2][CH:3]=5)[CH2:33]4)=[CH:28][CH:27]=3)[N:23]=[C:22]([NH2:36])[N:21]=2)[CH2:18][CH2:19]1

Participants

3

Reactant 2

HCID 64801Benzenepropanoyl chlorideHCID 675414894-(4-methylpiperazin-1-yl)-6-(1,2,3,4-tetrahydroisoquinolin-7-yl)pyrimidin-2-amine HCl salt

Product 1

HCID 59496704HCID 59496704, compound

Procedure

This compound was prepared by using procedures analogous to those described for the synthesis of Example 2 starting from benzenepropanoyl chloride (Aldrich, Cat. #249440) and 4-(4-methylpiperazin-1-yl)-6-(1,2,3,4-tetrahydroisoquinolin-7-yl)pyrimidin-2-amine HCl salt. Analytic LCMS (M+H)+: m/z=457.2.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-0ab27497ea814cfbabdafb0ea1bacc6f
Source dataset
uspto-grants-2013_07
Patent number
US08481732B2

Reaction notes

Loading…