2-Cyclohexylpropionic acid → HCID 59496561, compound

HRID 449426Notes

Reaction equation

HRID 449426 reaction equation
[CH:1]1([CH:7]([CH3:11])[C:8]([OH:10])=O)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.Cl.[CH3:13][N:14]1[CH2:19][CH2:18][N:17]([C:20]2[CH:25]=[C:24]([C:26]3[CH:35]=[C:34]4[C:29]([CH2:30][CH2:31][NH:32][CH2:33]4)=[CH:28][CH:27]=3)[N:23]=[C:22]([NH2:36])[N:21]=2)[CH2:16][CH2:15]1>>[CH:1]1([CH:7]([CH3:11])[C:8]([N:32]2[CH2:31][CH2:30][C:29]3[C:34](=[CH:35][C:26]([C:24]4[CH:25]=[C:20]([N:17]5[CH2:16][CH2:15][N:14]([CH3:13])[CH2:19][CH2:18]5)[N:21]=[C:22]([NH2:36])[N:23]=4)=[CH:27][CH:28]=3)[CH2:33]2)=[O:10])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

3

Reactant 2

HCID 998162-Cyclohexylpropionic acidHCID 675414894-(4-methylpiperazin-1-yl)-6-(1,2,3,4-tetrahydroisoquinolin-7-yl)pyrimidin-2-amine HCl salt

Product 1

HCID 59496561HCID 59496561, compound

Procedure

This compound was prepared by using procedures analogous to those described for the synthesis of Example 41 starting from 2-cyclohexylpropanoic acid and 4-(4-methylpiperazin-1-yl)-6-(1,2,3,4-tetrahydroisoquinolin-7-yl)pyrimidin-2-amine HCl salt. Analytic LCMS (M+H)+: m/z=463.3.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-9add27c64fea4a089a52007d6180803a
Source dataset
uspto-grants-2013_07
Patent number
US08481732B2

Reaction notes

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