4,4-Difluoropiperidine → HCID 59496622, compound

HRID 449429Notes

Reaction equation

HRID 449429 reaction equation
[F:1][C:2]1([F:8])[CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1.[NH2:9][C:10]1[N:15]=[C:14]([C:16]2[CH:25]=[C:24]3[C:19]([CH2:20][CH2:21][N:22]([C:26](OC4C=CC([N+]([O-])=O)=CC=4)=[O:27])[CH2:23]3)=[CH:18][CH:17]=2)[CH:13]=[C:12]([N:38]2[CH2:43][CH2:42][N:41]([CH3:44])[CH2:40][CH2:39]2)[N:11]=1>>[F:1][C:2]1([F:8])[CH2:7][CH2:6][N:5]([C:26]([N:22]2[CH2:21][CH2:20][C:19]3[C:24](=[CH:25][C:16]([C:14]4[CH:13]=[C:12]([N:38]5[CH2:39][CH2:40][N:41]([CH3:44])[CH2:42][CH2:43]5)[N:11]=[C:10]([NH2:9])[N:15]=4)=[CH:17][CH:18]=3)[CH2:23]2)=[O:27])[CH2:4][CH2:3]1

Participants

3

Reactant 2

HCID 27583524,4-DifluoropiperidineHCID 59496719HCID 59496719, compound

Product 1

HCID 59496622HCID 59496622, compound

Procedure

This compound was prepared by using procedures analogous to those described for the synthesis of Example 103, Step 2 starting from 4,4-difluoropiperidine (Ryan Scientific, Cat. #1006) and 4-nitrophenyl 7-[2-amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]-3,4-dihydroisoquinoline-2(1H)-carboxylate. Analytic LCMS (M+H)+: m/z=472.2.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-68244a39d158472093bf93d0d0353577
Source dataset
uspto-grants-2013_07
Patent number
US08481732B2

Reaction notes

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