Cyclohexanecarboxylic acid → HCID 67542834, compound

HRID 449430Notes

Reaction equation

HRID 449430 reaction equation
[CH:1]1([C:7]([OH:9])=O)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.Cl.[CH3:11][N:12]1[CH2:17][CH2:16][N:15]([C:18]2[CH:23]=[C:22]([C:24]3[CH:33]=[C:32]4[C:27]([CH2:28][CH2:29][NH:30][CH2:31]4)=[CH:26][CH:25]=3)[N:21]=[C:20]([NH2:34])[N:19]=2)[CH2:14][CH2:13]1>>[CH:1]1([C:7]([N:30]2[CH2:29][CH2:28][C:27]3[C:32](=[CH:33][C:24]([C:22]4[CH:23]=[C:18]([N:15]5[CH2:14][CH2:13][N:12]([CH3:11])[CH2:17][CH2:16]5)[N:19]=[C:20]([NH2:34])[N:21]=4)=[CH:25][CH:26]=3)[CH2:31]2)=[O:9])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

3

Reactant 2

HCID 7413Cyclohexanecarboxylic acidHCID 675414894-(4-methylpiperazin-1-yl)-6-(1,2,3,4-tetrahydroisoquinolin-7-yl)pyrimidin-2-amine HCl salt

Product 1

HCID 67542834HCID 67542834, compound

Procedure

This compound was prepared by using procedures analogous to those described for the synthesis of Example 41 starting from cyclohexanecarboxylic acid (Aldrich, Cat. #101834) and 4-(4-methylpiperazin-1-yl)-6-(1,2,3,4-tetrahydroisoquinolin-7-yl)pyrimidin-2-amine HCl salt. Analytic LCMS (M+H)+: m/z=435.2.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-58eb095e0f0b432cbaef54f71e0bd120
Source dataset
uspto-grants-2013_07
Patent number
US08481732B2

Reaction notes

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