Cyclopropaneacetic acid → HCID 59496567, compound

HRID 449431Notes

Reaction equation

HRID 449431 reaction equation
[CH:1]1([CH2:4][C:5]([OH:7])=O)[CH2:3][CH2:2]1.Cl.[CH3:9][N:10]1[CH2:15][CH2:14][N:13]([C:16]2[CH:21]=[C:20]([C:22]3[CH:31]=[C:30]4[C:25]([CH2:26][CH2:27][NH:28][CH2:29]4)=[CH:24][CH:23]=3)[N:19]=[C:18]([NH2:32])[N:17]=2)[CH2:12][CH2:11]1>>[CH:1]1([CH2:4][C:5]([N:28]2[CH2:27][CH2:26][C:25]3[C:30](=[CH:31][C:22]([C:20]4[CH:21]=[C:16]([N:13]5[CH2:12][CH2:11][N:10]([CH3:9])[CH2:15][CH2:14]5)[N:17]=[C:18]([NH2:32])[N:19]=4)=[CH:23][CH:24]=3)[CH2:29]2)=[O:7])[CH2:2][CH2:3]1

Participants

3

Reactant 2

HCID 138440Cyclopropaneacetic acidHCID 675414894-(4-methylpiperazin-1-yl)-6-(1,2,3,4-tetrahydroisoquinolin-7-yl)pyrimidin-2-amine HCl salt

Product 1

HCID 59496567HCID 59496567, compound

Procedure

This compound was prepared by using procedures analogous to those described for the synthesis of Example 41 starting from cyclopropylacetic acid (Oakwood, Cat. #003710) and 4-(4-methylpiperazin-1-yl)-6-(1,2,3,4-tetrahydroisoquinolin-7-yl)pyrimidin-2-amine HCl salt. Analytic LCMS (M+H)+: m/z=407.2.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-b2bac62e7d9042aa941982afc7fd13ab
Source dataset
uspto-grants-2013_07
Patent number
US08481732B2

Reaction notes

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