4-Cyanophenylacetic acid → HCID 59496660, compound

HRID 449432Notes

Reaction equation

HRID 449432 reaction equation
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([CH2:9][C:10]([OH:12])=O)=[CH:5][CH:4]=1)#[N:2].Cl.[CH3:14][N:15]1[CH2:20][CH2:19][N:18]([C:21]2[CH:26]=[C:25]([C:27]3[CH:36]=[C:35]4[C:30]([CH2:31][CH2:32][NH:33][CH2:34]4)=[CH:29][CH:28]=3)[N:24]=[C:23]([NH2:37])[N:22]=2)[CH2:17][CH2:16]1>>[NH2:37][C:23]1[N:24]=[C:25]([C:27]2[CH:36]=[C:35]3[C:30]([CH2:31][CH2:32][N:33]([C:10](=[O:12])[CH2:9][C:6]4[CH:5]=[CH:4][C:3]([C:1]#[N:2])=[CH:8][CH:7]=4)[CH2:34]3)=[CH:29][CH:28]=2)[CH:26]=[C:21]([N:18]2[CH2:17][CH2:16][N:15]([CH3:14])[CH2:20][CH2:19]2)[N:22]=1

Participants

3

Reactant 2

HCID 795874-Cyanophenylacetic acidHCID 675414894-(4-methylpiperazin-1-yl)-6-(1,2,3,4-tetrahydroisoquinolin-7-yl)pyrimidin-2-amine HCl salt

Product 1

HCID 59496660HCID 59496660, compound

Procedure

This compound was prepared by using procedures analogous to those described for the synthesis of Example 41 starting from (4-cyanophenyl)acetic acid (Aldrich, Cat. #633453) and 4-(4-methylpiperazin-1-yl)-6-(1,2,3,4-tetrahydroisoquinolin-7-yl)pyrimidin-2-amine HCl salt. Analytic LCMS (M+H)+: m/z=468.1.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-76bfee00a7a24808b690004788df9839
Source dataset
uspto-grants-2013_07
Patent number
US08481732B2

Reaction notes

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