2-cyclobutylacetic Acid → HCID 59496604, compound

HRID 449434Notes

Reaction equation

HRID 449434 reaction equation
[CH:1]1([CH2:5][C:6]([OH:8])=O)[CH2:4][CH2:3][CH2:2]1.Cl.[CH3:10][N:11]1[CH2:16][CH2:15][N:14]([C:17]2[CH:22]=[C:21]([C:23]3[CH:32]=[C:31]4[C:26]([CH2:27][CH2:28][NH:29][CH2:30]4)=[CH:25][CH:24]=3)[N:20]=[C:19]([NH2:33])[N:18]=2)[CH2:13][CH2:12]1>>[CH:1]1([CH2:5][C:6]([N:29]2[CH2:28][CH2:27][C:26]3[C:31](=[CH:32][C:23]([C:21]4[CH:22]=[C:17]([N:14]5[CH2:13][CH2:12][N:11]([CH3:10])[CH2:16][CH2:15]5)[N:18]=[C:19]([NH2:33])[N:20]=4)=[CH:24][CH:25]=3)[CH2:30]2)=[O:8])[CH2:2][CH2:3][CH2:4]1

Participants

3

Reactant 2

HCID 15164112-cyclobutylacetic AcidHCID 675414894-(4-methylpiperazin-1-yl)-6-(1,2,3,4-tetrahydroisoquinolin-7-yl)pyrimidin-2-amine HCl salt

Product 1

HCID 59496604HCID 59496604, compound

Procedure

This compound was prepared by using procedures analogous to those described for the synthesis of Example 41 starting from cyclobutylacetic acid and 4-(4-methylpiperazin-1-yl)-6-(1,2,3,4-tetrahydroisoquinolin-7-yl)pyrimidin-2-amine HCl salt. Analytic LCMS (M+H)+: m/z=421.1.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-05826b03babb42a4ab1aaceea902b042
Source dataset
uspto-grants-2013_07
Patent number
US08481732B2

Reaction notes

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