HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrahydropyran-4-ylacetic acid → 4-(4-Methylpiperazin-1-yl)-6-[2-(tetrahydro-2H-pyran-4-ylacetyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyrimidin-2-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrahydropyran-4-ylacetic acid | HCID 2773575 | — |
| Reactant | 4-(4-methylpiperazin-1-yl)-6-(1,2,3,4-tetrahydroisoquinolin-7-yl)pyrimidin-2-amine HCl salt | HCID 67541489 | — |
| Product | 4-(4-Methylpiperazin-1-yl)-6-[2-(tetrahydro-2H-pyran-4-ylacetyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyrimidin-2-amine | HCID 49779831 | — |
Reaction Steps
This compound was prepared by using procedures analogous to those described for the synthesis of Example 41 starting from tetrahydro-2H-pyran-4-ylacetic acid (Combi-Blocks, Cat. #AM-1005) and 4-(4-methylpiperazin-1-yl)-6-(1,2,3,4-tetrahydroisoquinolin-7-yl)pyrimidin-2-amine HCl salt. Analytic LCMS (M+H)+: m/z=451.1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08481732B2 |
| Source dataset | uspto-grants-2013_07 |
| ORD ID | ord-ead0da3e8a8a4148bb1c6e5329d6a4c8 |
| Source note | uspto-grants-2013_07 |