3-Methylpentanoic acid → 4-[2-(3-Methylpentanoyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]-6-(4-methylpiperazin-1-yl)pyrimidin-2-amine

HRID 449436Notes

Reaction equation

HRID 449436 reaction equation
[CH3:1][CH:2]([CH2:7][CH3:8])[CH2:3][C:4]([OH:6])=O.Cl.[CH3:10][N:11]1[CH2:16][CH2:15][N:14]([C:17]2[CH:22]=[C:21]([C:23]3[CH:32]=[C:31]4[C:26]([CH2:27][CH2:28][NH:29][CH2:30]4)=[CH:25][CH:24]=3)[N:20]=[C:19]([NH2:33])[N:18]=2)[CH2:13][CH2:12]1>>[CH3:1][CH:2]([CH2:7][CH3:8])[CH2:3][C:4]([N:29]1[CH2:28][CH2:27][C:26]2[C:31](=[CH:32][C:23]([C:21]3[CH:22]=[C:17]([N:14]4[CH2:13][CH2:12][N:11]([CH3:10])[CH2:16][CH2:15]4)[N:18]=[C:19]([NH2:33])[N:20]=3)=[CH:24][CH:25]=2)[CH2:30]1)=[O:6]

Participants

3

Reactant 2

HCID 77553-Methylpentanoic acidHCID 675414894-(4-methylpiperazin-1-yl)-6-(1,2,3,4-tetrahydroisoquinolin-7-yl)pyrimidin-2-amine HCl salt

Product 1

HCID 497798324-[2-(3-Methylpentanoyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]-6-(4-methylpiperazin-1-yl)pyrimidin-2-amine

Procedure

This compound was prepared by using procedures analogous to those described for the synthesis of Example 41 starting from 3-methylpentanoic acid (Aldrich, Cat. #223453) and 4-(4-methylpiperazin-1-yl)-6-(1,2,3,4-tetrahydroisoquinolin-7-yl)pyrimidin-2-amine HCl salt. Analytic LCMS (M+H)+: m/z=423.2.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-c77cd80359e84281bb83a2e60e6d3d5d
Source dataset
uspto-grants-2013_07
Patent number
US08481732B2

Reaction notes

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