3-[(Methoxycarbonyl)amino]butanoic acid → methyl {3-[7-[2-amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]-3,4-dihydroisoquinolin-2(1H)-yl]-1-methyl-3-oxopropyl}carbamate

HRID 449439Notes

Reaction equation

HRID 449439 reaction equation
[CH3:1][O:2][C:3]([NH:5][CH:6]([CH3:11])[CH2:7][C:8](O)=[O:9])=[O:4].Cl.[CH3:13][N:14]1[CH2:19][CH2:18][N:17]([C:20]2[CH:25]=[C:24]([C:26]3[CH:35]=[C:34]4[C:29]([CH2:30][CH2:31][NH:32][CH2:33]4)=[CH:28][CH:27]=3)[N:23]=[C:22]([NH2:36])[N:21]=2)[CH2:16][CH2:15]1>>[CH3:1][O:2][C:3](=[O:4])[NH:5][CH:6]([CH3:11])[CH2:7][C:8]([N:32]1[CH2:31][CH2:30][C:29]2[C:34](=[CH:35][C:26]([C:24]3[CH:25]=[C:20]([N:17]4[CH2:16][CH2:15][N:14]([CH3:13])[CH2:19][CH2:18]4)[N:21]=[C:22]([NH2:36])[N:23]=3)=[CH:27][CH:28]=2)[CH2:33]1)=[O:9]

Participants

3

Reactant 2

HCID 224063953-[(Methoxycarbonyl)amino]butanoic acidHCID 675414894-(4-methylpiperazin-1-yl)-6-(1,2,3,4-tetrahydroisoquinolin-7-yl)pyrimidin-2-amine HCl salt

Product 1

HCID 49779834methyl {3-[7-[2-amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]-3,4-dihydroisoquinolin-2(1H)-yl]-1-methyl-3-oxopropyl}carbamate

Procedure

This compound was prepared by using procedures analogous to those described for the synthesis of Example 41 starting from 3-[(methoxycarbonyl)amino]butanoic acid and 4-(4-methylpiperazin-1-yl)-6-(1,2,3,4-tetrahydroisoquinolin-7-yl)pyrimidin-2-amine HCl salt. Analytic LCMS (M+H)+: m/z=468.2.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-6d8c6900a12a4e05b7b0ac97abaeb961
Source dataset
uspto-grants-2013_07
Patent number
US08481732B2

Reaction notes

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