HCID 59496620, compound → HCID 49779835, compound

HRID 449441Notes

Reaction equation

HRID 449441 reaction equation
[CH:1]1([CH:7]([NH:12][C:13]([O:15][CH3:16])=[O:14])[CH2:8][C:9]([OH:11])=O)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.Cl.[CH3:18][N:19]1[CH2:24][CH2:23][N:22]([C:25]2[CH:30]=[C:29]([C:31]3[CH:40]=[C:39]4[C:34]([CH2:35][CH2:36][NH:37][CH2:38]4)=[CH:33][CH:32]=3)[N:28]=[C:27]([NH2:41])[N:26]=2)[CH2:21][CH2:20]1>>[CH3:16][O:15][C:13](=[O:14])[NH:12][CH:7]([CH:1]1[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1)[CH2:8][C:9]([N:37]1[CH2:36][CH2:35][C:34]2[C:39](=[CH:40][C:31]([C:29]3[CH:30]=[C:25]([N:22]4[CH2:21][CH2:20][N:19]([CH3:18])[CH2:24][CH2:23]4)[N:26]=[C:27]([NH2:41])[N:28]=3)=[CH:32][CH:33]=2)[CH2:38]1)=[O:11]

Participants

3

Reactant 2

HCID 59496620HCID 59496620, compoundHCID 675414894-(4-methylpiperazin-1-yl)-6-(1,2,3,4-tetrahydroisoquinolin-7-yl)pyrimidin-2-amine HCl salt

Product 1

HCID 49779835HCID 49779835, compound

Procedure

This compound was prepared by using procedures analogous to those described for the synthesis of Example 41 starting from 3-cyclohexyl-3-[(methoxycarbonyl)amino]propanoic acid and 4-(4-methylpiperazin-1-yl)-6-(1,2,3,4-tetrahydroisoquinolin-7-yl)pyrimidin-2-amine HCl salt. Analytic LCMS (M+H)+: m/z=536.2.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-676c19d72d0441bd9e065dac8b31ceb6
Source dataset
uspto-grants-2013_07
Patent number
US08481732B2

Reaction notes

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