Ethyl chloroformate → 1-(Ethoxycarbonyl)piperidin-4-yl 7-[2-amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]-3,4-dihydroisoquinoline-2(1h)-carboxylate

Participants

Role	Name	HCID	Charge
Reactant	Ethyl chloroformate	HCID 10928	—
Reactant	piperidin-4-yl 7-[2-amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]-3,4-dihydroisoquinoline-2(1H)-carboxylate HCl salt	HCID 67541330	—
Product	1-(Ethoxycarbonyl)piperidin-4-yl 7-[2-amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]-3,4-dihydroisoquinoline-2(1h)-carboxylate	HCID 49779902	—

Reaction Steps

This compound was prepared by using procedures analogous to those described for the synthesis of Example 67, Step 4 starting from ethyl chloroformate and piperidin-4-yl 7-[2-amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]-3,4-dihydroisoquinoline-2(1H)-carboxylate HCl salt. Analytic LCMS (M+H)+: m/z=524.3.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08481732B2
Source dataset	uspto-grants-2013_07
ORD ID	ord-82db54a6f3b940c69e8e67080087c071
Source note	uspto-grants-2013_07