Isopropyl chloroformate → HCID 59496744, compound

HRID 449447Notes

Reaction equation

Cl[C:2]([O:4][CH:5]([CH3:7])[CH3:6])=[O:3].Cl.[CH3:9][N:10]1[CH2:15][CH2:14][N:13]([C:16]2[CH:21]=[C:20]([C:22]3[CH:31]=[C:30]4[C:25]([CH2:26][CH2:27][N:28]([C:32](=[O:39])[CH2:33][CH:34]5[CH2:38][CH2:37][NH:36][CH2:35]5)[CH2:29]4)=[CH:24][CH:23]=3)[N:19]=[C:18]([NH2:40])[N:17]=2)[CH2:12][CH2:11]1>>[NH2:40][C:18]1[N:19]=[C:20]([C:22]2[CH:31]=[C:30]3[C:25]([CH2:26][CH2:27][N:28]([C:32](=[O:39])[CH2:33][CH:34]4[CH2:38][CH2:37][N:36]([C:2]([O:4][CH:5]([CH3:7])[CH3:6])=[O:3])[CH2:35]4)[CH2:29]3)=[CH:24][CH:23]=2)[CH:21]=[C:16]([N:13]2[CH2:12][CH2:11][N:10]([CH3:9])[CH2:15][CH2:14]2)[N:17]=1

Participants

Reactant 2

HCID 7917Isopropyl chloroformate

HCID 67542416HCID 67542416, compound

Product 1

HCID 59496744HCID 59496744, compound

Procedure

This compound was prepared by using procedures analogous to those described for the synthesis of Example 118, Step 3 starting from isopropyl chloroformate and 4-(4-methylpiperazin-1-yl)-6-[2-(pyrrolidin-3-ylacetyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyrimidin-2-amine HCl salt. Analytic LCMS (M+H)+: m/z=522.2.

Workup

customThis compound was prepared

Sources & evidence

ORD record: ord-bdd97a38c89048418adbdbcbedcb4b89
Source dataset: uspto-grants-2013_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08481732B2

Reaction notes

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