3-Cyano-3-phenylpropanoic acid → 4-[7-[2-Amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]-3,4-dihydroisoquinolin-2(1h)-yl]-4-oxo-2-phenylbutanenitrile

Participants

Role	Name	HCID	Charge
Reactant	3-Cyano-3-phenylpropanoic acid	HCID 11194625	—
Reactant	piperidin-4-yl 7-[2-amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]-3,4-dihydroisoquinoline-2(1H)-carboxylate HCl salt	HCID 67541330	—
Product	4-[7-[2-Amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]-3,4-dihydroisoquinolin-2(1h)-yl]-4-oxo-2-phenylbutanenitrile	HCID 59496697	—

Reaction Steps

This compound was prepared by using procedures analogous to those described for the synthesis of Example 120, Step 4 starting from 3-cyano-3-phenylpropanoic acid and piperidin-4-yl 7-[2-amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]-3,4-dihydroisoquinoline-2(1H)-carboxylate HCl salt. Analytic LCMS (M+H)+: m/z=482.1.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08481732B2
Source dataset	uspto-grants-2013_07
ORD ID	ord-05420d6cdd0e4946b02ad7d2f0bb2755
Source note	uspto-grants-2013_07