HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosgene → 7-[2-Amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]-N-(1-pyridin-3-ylethyl)-3,4-dihydroisoquinoline-2(1H)-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosgene | HCID 6371 | — |
| Reactant | 1-(Pyridin-3-yl)ethan-1-amine | HCID 2771688 | — |
| Reactant | 4-(4-methylpiperazin-1-yl)-6-(1,2,3,4-tetrahydroisoquinolin-7-yl)pyrimidin-2-amine HCl salt | HCID 67541489 | — |
| Product | 7-[2-Amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]-N-(1-pyridin-3-ylethyl)-3,4-dihydroisoquinoline-2(1H)-carboxamide | HCID 59496666 | — |
Reaction Steps
This compound was prepared by using procedures analogous to those described for the synthesis of Example 40 starting from 1-pyridin-3-ylethanamine (Enamine, Cat. #EN300-12752), phosgene and 4-(4-methylpiperazin-1-yl)-6-(1,2,3,4-tetrahydroisoquinolin-7-yl)pyrimidin-2-amine HCl salt. Analytic LCMS (M+H)+: m/z=473.1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08481732B2 |
| Source dataset | uspto-grants-2013_07 |
| ORD ID | ord-ac0b04f0e2f441c182ace1961aeb2e0c |
| Source note | uspto-grants-2013_07 |