HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → methyl (2S)-2-amino-3-(4-isopropoxyphenyl)propanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | (S)-methyl 2-(tert-butoxycarbonylamino)-3-(4-isopropoxyphenyl)propanoate | HCID 59496538 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | methyl (2S)-2-amino-3-(4-isopropoxyphenyl)propanoate | HCID 59496671 | 100% |
Reaction Steps
Trifluoroacetic acid (0.5 mL, 6 mmol) was added to the (S)-methyl 2-(tert-butoxycarbonylamino)-3-(4-isopropoxyphenyl)propanoate in methylene chloride (2 mL). The reaction was stirred for 1 h., and was concentrated under reduced pressure to give a crude product, methyl (2S)-2-amino-3-(4-isopropoxyphenyl)propanoate (40 mg, 100%) as colorless oil. Analytical LCMS (M+H)+: m/z=238.0.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08481732B2 |
| Source dataset | uspto-grants-2013_07 |
| ORD ID | ord-55c6b53354c84e3fa698d72a813fa617 |
| Source note | uspto-grants-2013_07 |