HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → (2S)-2-amino-3-(4-isopropoxyphenyl)propanenitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | (S)-tert-butyl 1-cyano-2-(4-isopropoxyphenyl)ethylcarbamate | HCID 59496725 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (2S)-2-amino-3-(4-isopropoxyphenyl)propanenitrile | HCID 59496533 | 111.8% |
Reaction Steps
Trifluoroacetic acid (1 mL, 10 mmol) was added to a solution of the (S)-tert-butyl 1-cyano-2-(4-isopropoxyphenyl)ethylcarbamate (40 mg) in methylene chloride (2 mL). After stirring for 1 h., the reaction was concentrated under reduced pressure to give the crude product (2S)-2-amino-3-(4-isopropoxyphenyl)propanenitrile (30 mg, 90%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08481732B2 |
| Source dataset | uspto-grants-2013_07 |
| ORD ID | ord-4982f29a1f2d473c921af8b9c687d731 |
| Source note | uspto-grants-2013_07 |