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Trifluoroacetic acid → (S)-Methyl 3-([1,1'-biphenyl]-4-yl)-2-aminopropanoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Trifluoroacetic acid | HCID 6422 | — |
| 反応物 | (S)-Methyl 3-([1,1'-biphenyl]-4-yl)-2-((tert-butoxycarbonyl)amino)propanoate | HCID 10286882 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | (S)-Methyl 3-([1,1'-biphenyl]-4-yl)-2-aminopropanoate | HCID 15714801 | 139.2% |
反応手順
Trifluoroacetic acid (1 mL, 10 mmol) was added to a solution of (S)-methyl 3-(biphenyl-4-yl)-2-(tert-butoxycarbonylamino)propanoate (30 mg) in methylene chloride (2 mL). The reaction was stirred for 1 h, and was concentrated under reduced pressure to give the crude product methyl (2S)-2-amino-3-biphenyl-4-ylpropanoate (30 mg, 100%). Analytical LCMS (M+H)+: m/z=256.1.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08481732B2 |
| 出典データセット | uspto-grants-2013_07 |
| ORD ID | ord-bfb890ae30d6422a97b9fc386f1177f8 |
| 出典メモ | uspto-grants-2013_07 |