Diisopropylethylamine → HCID 49778964, compound

Participants

Reaction Steps

A solution of 2-amino-3-(benzo[d]thiazol-2-yl)-N,N-dimethylpropanamide (12.1 mg, 52.2 μmol), 2-amino-4-(4-methylpiperazin-1-yl)quinazoline-7-carboxylic acid (10 mg, 34.8 μmol) from Example 21 Step 4, N,N,N′,N′-tetramethyl-o-(7-azabenzotriazol-1-yl)uronium hexafluorophosphate (21.2 mg, 55.7 μmol), N,N-dimethylformamide (2 mL) and N,N-diisopropylethylamine (12.1 μl, 69.6 μmol) was stirred at 25° C. for 60 min The reaction was purified by prep RP-HPLC (pH=10) to afford the desired compound (0.009 g, 49%) as an amorphous white solid. Analytical LCMS (M+H)+: m/z=519.0.

Provenance & Evidence