HCID 136346398, compound → HCID 59496766, compound

Participants

Reaction Steps

Zinc (60 mg, 0.9 mmol) was added to a solution of a mixture of 2-biphenyl-4-yl-1-(1,3-thiazol-2-yl)ethanone oxime (60 mg) in acetic acid (1 mL). The reaction was stirred for 3 h., was filtered and concentrated under reduced pressure. The crude was made basic with saturated NaHCO3, and was extracted with ethyl acetate. The organic layer was washed with saturated brine, dried over magnesium sulfate, filtered and concentrated under reduced pressure to give 2-biphenyl-4-yl-1-(1,3-thiazol-2-yl)ethanamine (40 mg, 80%) as a white solid. Analytical LCMS (M+H)+: m/z=280.9.

Provenance & Evidence