HCID 66742512, compound → HCID 66742896, compound

HRID 449569Notes

Reaction equation

HRID 449569 reaction equation
[C:1]([C:5]1[CH:6]=[C:7]2[C:12](=[C:13]([F:15])[CH:14]=1)[C:11](=[O:16])[N:10]([C:17]1[C:18]([CH2:53][OH:54])=[C:19]([C:23]3[CH:24]=[C:25]([NH:31][C:32]4[N:37]=[CH:36][C:35]([N:38]5[CH:43]6[CH2:44][CH2:45][CH:39]5[CH2:40][N:41](C(OC(C)(C)C)=O)[CH2:42]6)=[CH:34][CH:33]=4)[C:26](=[O:30])[N:27]([CH3:29])[N:28]=3)[CH:20]=[CH:21][CH:22]=1)[N:9]=[CH:8]2)([CH3:4])([CH3:3])[CH3:2]>ClCCl>[CH:39]12[N:38]([C:35]3[CH:34]=[CH:33][C:32]([NH:31][C:25]4[C:26](=[O:30])[N:27]([CH3:29])[N:28]=[C:23]([C:19]5[C:18]([CH2:53][OH:54])=[C:17]([N:10]6[N:9]=[CH:8][C:7]7[C:12](=[C:13]([F:15])[CH:14]=[C:5]([C:1]([CH3:4])([CH3:2])[CH3:3])[CH:6]=7)[C:11]6=[O:16])[CH:22]=[CH:21][CH:20]=5)[CH:24]=4)=[N:37][CH:36]=3)[CH:43]([CH2:44][CH2:45]1)[CH2:42][NH:41][CH2:40]2

Participants

3

Reactant 1

HCID 66742512HCID 66742512, compound

Product 1

HCID 66742896HCID 66742896, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

tert-butyl 8-(6-(6-(3-(6-tert-butyl-8-fluoro-1-oxophthalazin-2(1H)-yl)-2-(hydroxymethyl)phenyl)-2-methyl-3-oxo-2,3-dihydropyridazin-4-ylamino)pyridin-3-yl)-3,8-diazabicyclo[3.2.1]octane-3-carboxylate (90 mg, 122 umol) was de-BOC with 50% trifluoro acid in dichloromethane (10 mL) for 2 hr. The reaction mixture was concentrated to dryness, then partitioned between ethyl acetate and saturated sodium bicarbonate. The organic phase was dried over sodium sulfate, filtered and concentrated.

Workup

  1. customfor 2 hr
  2. concentrationThe reaction mixture was concentrated to dryness
  3. custompartitioned between ethyl acetate and saturated sodium bicarbonate
  4. dry with materialThe organic phase was dried over sodium sulfate
  5. filtrationfiltered
  6. concentrationconcentrated

Sources & evidence

ORD record
ord-7a2376d6b7914b3d8ab5f493e98fd492
Source dataset
uspto-grants-2013_07
Patent number
US08481540B2

Reaction notes

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